Leonard Appleman: search on Z-Library

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1

Clinical activity of nivolumab in patients with non-clear cell renal cell carcinoma

Koshkin, Vadim S., Barata, Pedro C., Zhang, Tian, George, Daniel J., Atkins, Michael B., Kelly, William J., Vogelzang, Nicholas J., Pal, Sumanta K., Hsu, JoAnn, Appleman, Leonard J., Ornstein, Moshe C

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2018

Language:

english

File:

PDF, 467 KB

english, 2018

2

Helper T cell anergy: from biochemistry to cancer pathophysiology and therapeutics

Leonard J. Appleman, Dimitrios Tzachanis, Thomas Grader-Beck, Andre A.F.L. van Puijenbroek, Vassiliki A. Boussiotis

Journal:

Journal of Molecular Medicine

Year:

2001

Language:

english

File:

PDF, 164 KB

english, 2001

3

Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside

Amjad, Ali I., Parikh, Rahul A., Appleman, Leonard J., Hahm, Eun-Ryeong, Singh, Kamayani, Singh, Shivendra V.

Journal:

Current Pharmacology Reports

Year:

2015

Language:

english

File:

PDF, 377 KB

english, 2015

4

Mifepristone: pharmacology and clinical impact in reproductive medicine, endocrinology and oncology

Im, Annie, Appleman, Leonard J

Journal:

Expert Opinion on Pharmacotherapy

Year:

2010

Language:

english

File:

PDF, 590 KB

english, 2010

5

Inhibiting Autophagy

Lotze, Michael T., Maranchie, Jodi, Appleman, Leonard

Journal:

The Cancer Journal

Year:

2013

Language:

english

File:

PDF, 212 KB

english, 2013

6

Tyrosine Kinase and Mammalian Target of Rapamycin Inhibitors in the Treatment of Advanced Renal Cell Carcinoma: Practical Clinical Implications of Pharmacologic Features

Parikh, Rahul A., Appleman, Leonard J., Beumer, Jan H., Matczak, Ewa, Chu, Edward

Journal:

Clinical Genitourinary Cancer

Year:

2016

Language:

english

File:

PDF, 463 KB

english, 2016

7

Mouse embryo fibroblasts transformed by activated ras or dominant-negative p53 express cross-reactive tumor rejection antigens

Leonard J. Appleman, James Uyeki, Alan B. Frey

Journal:

International Journal of Cancer

Year:

1995

Language:

english

File:

PDF, 929 KB

english, 1995

8

Phase I study of veliparib in combination with gemcitabine

Stoller, Ronald, Schmitz, John C., Ding, Fei, Puhalla, Shannon, Belani, Chandra P., Appleman, Leonard, Lin, Yan, Jiang, Yixing, Almokadem, Salah, Petro, Daniel, Holleran, Julianne, Kiesel, Brian F., K

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2017

Language:

english

File:

PDF, 757 KB

english, 2017

9

MP70-20 A PHASE 2 TRIAL OF PROSTATE SPECIFIC MEMBRANE ANTIGEN ANTIBODY DRUG CONJUGATE (PSMA ADC) IN TAXANE-TREATED METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC)

Petrylak, Daniel, Smith, David C., Appleman, Leonard J., Fleming, Mark, Hussain, Arif, Dreicer, Robert, Sartor, A. Oliver, Shore, Neil, Vogelzang, Nicholas J., Youssoufian, Hagop, Olson, William, Stam

Journal:

The Journal of Urology

Year:

2014

Language:

english

File:

PDF, 311 KB

english, 2014

10

Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas

Parikh, Rahul A., Appleman, Leonard J., Bauman, Julie E., Sankunny, Madhav, Lewis, Dale W., Vlad, Anda, Gollin, Susanne M.

Journal:

Genes, Chromosomes and Cancer

Year:

2014

Language:

english

File:

PDF, 1.32 MB

english, 2014

11

A randomized phase 2 trial of pembrolizumab versus pembrolizumab and acalabrutinib in patients with platinumâresistant metastatic urothelial cancer

Zhang, Tian, Harrison, Michael R., O'Donnell, Peter H., Alva, Ajjai S., Hahn, Noah M., Appleman, Leonard J., Cetnar, Jeremy, Burke, John M., Fleming, Mark T., Milowsky, Matthew I., Mortazavi, Amir, Sh

Journal:

Year:

2020

File:

PDF, 536 KB

2020

12

Phase I clinical trial of bortezomib in combination with gemcitabine in patients with advanced solid tumors

David P. Ryan, Leonard J. Appleman, Thomas Lynch, Jeffrey G. Supko, Panagiotis Fidias, Jeffrey W. Clark, Mayer Fishman, Andrew X. Zhu, Peter C. Enzinger, Oscar Kashala, James Cusack Jr., Joseph P. Ede

Journal:

Year:

2006

Language:

english

File:

PDF, 114 KB

english, 2006

13

Radium-223 Therapy for Patients with Metastatic Castrate-Resistant Prostate Cancer: An Update on Literature with Case Presentation

Nguyen, Nghi C., Shah, Muhammad, Appleman, Leonard J., Parikh, Rahul, Mountz, James M.

Journal:

International Journal of Molecular Imaging

Year:

2016

Language:

english

File:

PDF, 2.64 MB

english, 2016

14

Rate and Determinants of Completing Neoadjuvant Chemotherapy in Medicare Beneficiaries with Bladder Cancer: A SEER-Medicare Analysis

Hugar, Lee A, Yabes, Jonathan G, Turner, Robert M, Fam, Mina M, Appleman, Leonard J, Davies, Benjamin J, Jacobs, Bruce L

Journal:

Year:

2018

Language:

english

File:

PDF, 672 KB

english, 2018

15

Effect of a proton pump inhibitor on the pharmacokinetics of imatinib

Merrill J. Egorin, Dhvani D. Shah, Susan M. Christner, Mara A. Yerk, Kristin A. Komazec, Leonard R. Appleman, Robert L. Redner, Brian M. Miller, Jan H. Beumer

Journal:

British Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 525 KB

english, 2009

16

Cabozantinib, a New Standard of Care for Patients With Advanced Renal Cell Carcinoma and Bone Metastases? Subgroup Analysis of the METEOR Trial

Escudier, Bernard, Powles, Thomas, Motzer, Robert J., Olencki, Thomas, Arén Frontera, Osvaldo, Oudard, Stephane, Rolland, Frederic, Tomczak, Piotr, Castellano, Daniel, Appleman, Leonard J., Drabkin, H

Journal:

Journal of Clinical Oncology

Year:

2018

File:

PDF, 803 KB

2018

17

A phase I open-label study evaluating the cardiovascular safety of sorafenib in patients with advanced cancer

Anthony W. Tolcher, Leonard J. Appleman, Geoffrey I. Shapiro, Alain C. Mita, Frank Cihon, Arthur Mazzu, Pavur R. Sundaresan

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 265 KB

english, 2011

18

Pharmacologic Administration of Interleukin-2 : Inducing a Systemic Autophagic Syndrome?

Antonio Romo de Vivar Chavez, William Buchser, Per H. Basse, Xiaoyan Liang, Leonard J. Appleman, Jodi K. Maranchie, Herbert Zeh, Michael E. de Vera, Michael T. Lotze

Journal:

Annals of the New York Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 460 KB

english, 2009

19

MP23-09 INTEGRATED ANALYSIS OF METASTATIC DISEASE IN CLEAR CELL RENAL CELL CARCINOMA: A COLLABORATIVE TCGA ANALYSIS

Hakimi, A Ari, Jacobsen, Anders, Mano, Roy, Gonen, Mithat, Voss, Martin H., Reuter, Victor E., Rathmell, W Kimryn, Maranchie, Jodi K., Appleman, Leonard J., Tamboli, Pheroze, Signoretti, Sabina, Choue

Journal:

The Journal of Urology

Year:

2014

Language:

english

File:

PDF, 196 KB

english, 2014

20

MP82-09 PROSTATE SPECIFIC MEMBRANE ANTIGEN ANTIBODY DRUG CONJUGATE (PSMA ADC) IN PATIENTS (PTS) WITH PROGRESSIVE METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC) FOLLOWING ABIRATERONE AND/OR ENZALUTAMIDE (ABI/ENZ): RESULTS FROM A PHASE 2 STUDY

Petrylak, Daniel, Vogelzang, Nicholas, Chatta, Kamal, Fleming, Mark, Smith, David, Appleman, Leonard, Hussain, Arif, Modiano, Manuel, Singh, Parminder, Tagawa, Scott, Gore, Ira, McClay, Ed, Mega, Anth

Journal:

The Journal of Urology

Year:

2015

Language:

english

File:

PDF, 336 KB

english, 2015

21

Phase 1 study of veliparib (ABT-888), a poly (ADP-ribose) polymerase inhibitor, with carboplatin and paclitaxel in advanced solid malignancies

Appleman, Leonard J., Beumer, Jan H., Jiang, Yixing, Lin, Yan, Ding, Fei, Puhalla, Shannon, Swartz, Leigh, Owonikoko, Taofeek K., Donald Harvey, R., Stoller, Ronald, Petro, Daniel P., Tawbi, Hussein A

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2019

Language:

english

File:

PDF, 1.01 MB

english, 2019

22

Renal Medullary Carcinoma: Case Report of an Aggressive Malignancy with Near-Complete Response to Dose-Dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Chemotherapy

Amjad, Ali Imran, Ali, Hira, Appleman, Leonard J., Maranchie, Jodi, Jackman, Stephen, Parwani, Anil, Dhir, Rajiv, Roy, Somak, Parikh, Rahul A.

Journal:

Case Reports in Oncological Medicine

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

23

Impact of annual hospital volume of high dose interleukin-2 infusions on in-patient mortality in patients with melanoma and renal cell carcinoma

Mehta, Kathan, Appleman, Leonard, Wang, Hong, Tarhini, Ahmad, Parikh, Rahul

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2015

Language:

english

File:

PDF, 424 KB

english, 2015

24

Phase 1 study of veliparib (ABT-888), a poly (ADP-ribose) polymerase inhibitor, with carboplatin and paclitaxel in advanced solid malignancies

Appleman, Leonard J., Beumer, Jan H., Jiang, Yixing, Lin, Yan, Ding, Fei, Puhalla, Shannon, Swartz, Leigh, Owonikoko, Taofeek K., Donald Harvey, R., Stoller, Ronald, Petro, Daniel P., Tawbi, Hussein A

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2019

File:

PDF, 1.01 MB

2019

25

Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies

Athanassios Argiris, Trevor M. Feinstein, Lin Wang, Tianbing Yang, Shruti Agrawal, Leonard J. Appleman, Ronald G. Stoller, Jennifer R. Grandis, Ann Marie Egloff

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 460 KB

english, 2012

26

Selective kinase inhibition with daily imatinib intensifies toxicity of chemotherapy in patients with solid tumours

Suzanne George, Jayesh Desai, J. Paul Eder, Judith Manola, David P. Ryan, Leonard J. Appleman, George D. Demetri

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 157 KB

english, 2006

27

Simple and Complex

Leng, Siyang, Nallamothu, Brahmajee K., Saint, Sanjay, Appleman, Leonard J., Bump, Gregory M.

Journal:

Boston Medical and Surgical Journal

Year:

2013

Language:

english

File:

PDF, 969 KB

english, 2013

28

Calcium carbonate does not affect nilotinib pharmacokinetics in healthy volunteers

Tawbi, Hussein A., Tran, An L., Christner, Susan M., Lin, Yan, Johnson, Matthew, Mowrey, Emily, Appleman, Leonard R., Stoller, Ronald, Miller, Brian M., Egorin, Merrill J., Beumer, Jan H.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2013

Language:

english

File:

PDF, 380 KB

english, 2013

29

Sarcomatoid Renal Cell Carcinoma: A Population-Based Study of 879 Patients

Alevizakos, Michail, Gaitanidis, Apostolos, Nasioudis, Dimitrios, Msaouel, Pavlos, Appleman, Leonard J.

Journal:

Clinical Genitourinary Cancer

Year:

2019

Language:

english

File:

PDF, 707 KB

english, 2019

30

Phase I trial of belinostat in combination with 13-cis-retinoic acid in advanced solid tumor malignancies: a California Cancer Consortium NCI/CTEP sponsored trial

Luu, Thehang, Frankel, Paul, Beumer, Jan H., Lim, Dean, Cristea, Mihaela, Appleman, Leonard J., Lenz, Heinz J., Gandara, David R., Kiesel, Brian F., Piekarz, Richard L., Newman, Edward M.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2019

Language:

english

File:

PDF, 680 KB

english, 2019

31

Molecular Subtypes Improve Prognostic Value of International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Model

de Velasco, Guillermo, Culhane, Aedín C., Fay, André P., Ari Hakimi, A., Voss, Martin H., Tannir, Nizar M., Tamboli, Pheroze, Appleman, Leonard J., Bellmunt, Joaquim, Kimryn Rathmell, W., Albiges, Lau

Journal:

Year:

2017

Language:

english

File:

PDF, 519 KB

english, 2017

32

Metastasectomy in Advanced Renal Cell Carcinoma: A Systematic Review

Achkar, Tala, Maranchie, Jodi K., Appleman, Leonard J.

Journal:

Year:

2019

Language:

english

File:

PDF, 82 KB

english, 2019

33

Systemic therapy following metastasectomy for renal cell carcinoma: Using insights from other clinical settings to address unanswered questions

Appleman, Leonard J., Maranchie, Jodi K.

Journal:

Urologic Oncology: Seminars and Original Investigations

Year:

2017

Language:

english

File:

PDF, 250 KB

english, 2017

34

PSMA ADC monotherapy in patients with progressive metastatic castration‐resistant prostate cancer following abiraterone and/or enzalutamide: Efficacy and safety in open‐label single‐arm phase 2 study

Petrylak, Daniel P., Vogelzang, Nicholas J., Chatta, Kamal, Fleming, Mark T., Smith, David C., Appleman, Leonard J., Hussain, Arif, Modiano, Manuel, Singh, Parminder, Tagawa, Scott T., Gore, Ira, McCl

Journal:

Year:

2019

Language:

english

File:

PDF, 941 KB

english, 2019

35

T cell anergy and costimulation

Leonard J. Appleman, Vassiliki A. Boussiotis

Journal:

Immunological Reviews

Year:

2003

Language:

english

File:

PDF, 1.00 MB

english, 2003

36

Rat Adenocarcinoma 13762 Expresses Tumor Rejection Antigens but Tumor-Bearing Animals Exhibit Tumor-Specific Immunesuppression

Alan B. Frey, Leonard J. Appleman

Journal:

Clinical Immunology and Immunopathology

Year:

1993

File:

PDF, 929 KB

1993

37

Calcium carbonate does not affect imatinib pharmacokinetics in healthy volunteers

Tawbi, Hussein, Christner, Susan M., Lin, Yan, Johnson, Matthew, Mowrey, Emily T., Cherrin, Craig, Chu, Edward, Lee, James J., Puhalla, Shannon, Stoller, Ronald, Appleman, Leonard R., Miller, Brian M.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2014

Language:

english

File:

PDF, 212 KB

english, 2014

38

ECOG-ACRIN (E4805) Randomized Phase II Study to Determine the Effect of 2 Different Doses of Aflibercept in Patients with Metastatic Renal Cell Carcinoma

Pili, Roberto, Jegede, Opeyemi, Carducci, Michael A., Manola, Judith, Groteluschen, David L., Appleman, Leonard L., Liu, Glenn, Shanks, James C., Dakhil, Shaker R., Dutcher, Janice, DiPaola, Robert S.

Journal:

Clinical Genitourinary Cancer

Year:

2017

Language:

english

File:

PDF, 1.19 MB

english, 2017

39

A Phase I study of bortezomib plus irinotecan in patients with advanced solid tumors

David P. Ryan, Bert H. O'Neil, Jeffrey G. Supko, Carlo M. Rocha Lima, E. Claire Dees, Leonard J. Appleman, Jeffrey Clark, Phinos Fidias, Robert Z. Orlowski, Oscar Kashala, Joseph P. Eder, James C. Cus

Journal:

Year:

2006

Language:

english

File:

PDF, 278 KB

english, 2006

40

Renal Cell Carcinoma from a Transplanted Allograft: Two Case Reports and a Review of the Literature

Wassim McHayleh, John P. Morcos, Tong Wu, Ron Shapiro, Samuel Yousem, Leonard Appleman, David M. Friedland

Journal:

Clinical Genitourinary Cancer

Year:

2008

Language:

english

File:

PDF, 565 KB

english, 2008

41

Cabozantinib, a New Standard of Care for Patients With Advanced Renal Cell Carcinoma and Bone Metastases? Subgroup Analysis of the METEOR Trial

Escudier, Bernard, Powles, Thomas, Motzer, Robert J., Olencki, Thomas, Arén Frontera, Osvaldo, Oudard, Stephane, Rolland, Frederic, Tomczak, Piotr, Castellano, Daniel, Appleman, Leonard J., Drabkin, H

Journal:

Journal of Clinical Oncology

Year:

2018

Language:

english

File:

PDF, 803 KB

english, 2018

42

Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 administered as a weekly 24

Joseph P. Eder, David P. Ryan, Leonard Appleman, Andrew X. Zhu, Thomas Puchalski, Xiaoying He, Daryl S. Sonnichsen, Michael Cooper, John Wright, Jeffrey W. Clark, Jeffrey G. Supko

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2006

Language:

english

File:

PDF, 276 KB

english, 2006

43

P-348 A phase I trial of gemcitabine followed by flavopiridol in patients with solid tumors

Goffin, John, Appleman, Leonard, Ryan, David, Fidias, Panos, Lucca, Joan, Regan, Eileen, Dimitrios Colevas, A., Eder, Joseph Paul, Supko, Jeffrey, Shapiro, Geoffrey

Journal:

Year:

2003

Language:

english

File:

PDF, 369 KB

english, 2003

44

Induction of Immunologic Tolerance for Allogeneic Hematopoietic Cell Transplantation

Appleman, Leonard J., Tzachanis, Dimitrios, Grader-Beck, Thomas, Van Puijenbroek, Andre A. F. L., Boussiotis, Vassiliki A.

Journal:

Leukemia and Lymphoma

Year:

2002

Language:

english

File:

PDF, 917 KB

english, 2002

45

Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium

Russell, Kira L., Gorgulho, Carolina Mendonça, Allen, Abigail, Vakaki, Marianna, Wang, Yue, Facciabene, Andrea, Lee, Daniel, Roy, Partha, Buchser, William J., Appleman, Leonard J., Maranchie, Jodi, St

Journal:

The Cancer Journal

Year:

2019

File:

PDF, 773 KB

2019

46

Dominant-negative p53 can restore tumorigenicity of L-929 cells in immunocompetent mice

Leonard J. Appleman, Alan B. Frey

Journal:

International Journal of Cancer

Year:

1995

Language:

english

File:

PDF, 987 KB

english, 1995

47

Phase 2 trial of linifanib (ABT-869) in patients with advanced renal cell cancer after sunitinib failure

Nizar M. Tannir, Yu-Ning Wong, Christian K. Kollmannsberger, Marc S. Ernstoff, David J. Perry, Leonard J. Appleman, Edwin M. Posadas, Daniel Cho, Toni K. Choueiri, Andrew Coates, Neeraj Gupta, Rajendr

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 322 KB

english, 2011

48

Tumor Antigens Encoded by Oncogenes and the Impact of Oncogenes upon the Immune Response

Leonard J. Appleman, Alan B. Frey

Journal:

Cellular Immunology

Year:

1996

Language:

english

File:

PDF, 110 KB

english, 1996

49

DLK1: A Novel Target for Immunotherapeutic Remodeling of the Tumor Blood Vasculature

Chi Sabins, Nina, Taylor, Jennifer L, Fabian, Kellsye PL, Appleman, Leonard J, Maranchie, Jodi K, Stolz, Donna Beer, Storkus, Walter J

Journal:

Molecular Therapy

Year:

2013

Language:

english

File:

PDF, 2.22 MB

english, 2013

50

Simultaneous quantitation of abiraterone, enzalutamide, N -desmethyl enzalutamide, and bicalutamide in human plasma by LC–MS/MS

Kim, Kyu-pyo, Parise, Robert A., Holleran, Julianne L., Lewis, Lionel D., Appleman, Leonard, van Erp, Nielka, Morris, Michael J., Beumer, Jan H.

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2017

Language:

english

File:

PDF, 528 KB

english, 2017

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